sociology
“How much freedom should front-line clinicians have in treating Covid-19 patients with unproven drugs?”
Length: Your essay should be between 2,000 and 2,800 words (or 6-8 double-space pages in Times New Roman 12 points).
Your final essay should engage at least three authors we discussed in class and you need to provide the corresponding quotes. Your essay also needs to make use of adequate academic formats of citation. I dont prefer any in particular as long as your citation format is the same throughout the text
In other words, your essay should offer your analysis and interpretation of the case you have selected and the ideas and arguments relevant to the topic of your topic that can found in the material we discussed in class. Analysis is the process of examining your data (case or event) and associated ideas in order to answer a question. Interpretation refers to a discussion of the meaning and implications of your answer to the conversations your paper addresses. In short, your final essay must show what you think about the topic you have selected and offer evidence to substantiate the argument you are presenting.
Structure and organization: 1. Title (and subtitle if necessary) It reflects the thesis or main point of your paper.
2. Introduction Typically, one paragraph. It announces the topic of the essay, your question, your thesis or argument, the evidence the essay will draw on, and how the paper will be organized.
3. The ethnographic case or event One or two paragraphs describing a specific case, event, or situation you want to discuss to illustrate your theoretical discussion Using a narrative voice, in this section you establish the setting of your analysis. When compellingly written, this section draws the reader into the setting It should also state why the case or event is relevant for your discussionnamely, what kind of question this case or event brings to the fore.
4. Why this case or event is relevant for your theoretical discussion In one or two paragraphs, this section should describe the main question or issue that your case brings forth. It also should connect this question or issue to broader conversations happening among the scholars in Science and Technology Studies that we discussed in class.
5. Theoretical discussion concerning your question In this section, you elaborate on what established scholars have said about the broader question you are addressing. Here is where you draw heavily on the readings, recorded material, discussions, etc. we had throughout the semester. Your goal here is to give your reader a sense of what the main point of each of the theorists you are citing is and how these points converse with each other.
6. Your contribution to that conversation Here is where you elaborate on your own perspective on the question you are discussing in your essay and explicitly state your argument (or thesis.) In other words, here you show to your reader what your contribution to this conversation is based on the analysis of your case or event. Does your example confirm or contradict what these theorists say? Be explicit in your argument. Dont be shy. You are also a scholar participating in an academic conversation.
7. Conclusion Return to the question you raised in the opening section. Briefly recapitulate the main points you developed in your essay Emphasize, clarify, and render compelling your argument
8. Bibliography List all the references you have used in your essay.
By Susan Dominus
Published Aug. 5, 2020 Updated Aug. 8, 2020
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Mangala Narasimhan, an intensive-care-unit doctor, started feeling impatient soon after the start of a meeting she
attended at Long Island Jewish Medical Center on May 13. She wanted to get back to the unit, but instead she was
sitting in a conference room with about a dozen colleagues. By then, the surge of Covid-19 cases, the waves of
suffering that had crashed down on her hospital for months, was beginning, miraculously, to recede. The throngs of
out-of-town health care workers who had come to New York City to help were also diminishing, heading home to
regions whose own times would come. Narasimhan and her team now had fewer hands to oversee new patients
coming in and the long-suffering ones on ventilators who were still in need of meticulous care. Long Island Jewish,
in Queens, had, at the time, treated more Covid-19 patients than any other hospital in the country; the doctors there
were still weary, still battered, their energy and time in need of careful rationing.
Narasimhan, who was in charge of more than 20 I.C.U.s across the Northwell Health system, knew heading into the
meeting that it might be tense. Adey Tsegaye, a pulmonary-critical-care doctor who was calling in remotely, shared
some of Narasimhans concerns. The meetings agenda included time for remarks from Alex Spyropoulos, a lead
researcher at the Feinstein Institutes for Medical Research the research arm of Northwell who was running a
clinical trial. The research was trying to determine whether a standard dose of an anticoagulant or a higher dose
yielded better outcomes for Covid-19 patients who were already on oxygen or a ventilator and were at high risk of
organ failure and clotting.
A doctor on Narasimhans unit had recently been at odds with a member of Spyropouloss research team. Stella
Hahn, a pulmonary-critical-care doctor, arrived at work the day before the meeting to find that a Covid-19 patient
had gone into cardiac arrest. She knew that the patient was enrolled in the clinical trial and had been randomly
assigned to receive either the standard dose of the anticoagulant or the higher one. As is always the case in the most
rigorous trials, neither the patient nor Hahn was supposed to know to which group this woman belonged. Double-
blind, randomized, controlled trials R.C.T.s are considered the gold standard in research because they do not
allow findings to be muddied by any individual doctors biases or assumptions. But Hahn believed that the patients
condition now called for the higher dose, which could potentially require the patients removal from the trial.
How much freedom should front-line clinicians have in treating Covid-19 patients with unproven
drugs? The question opened up a civil war in some hospitals.
The Covid Drug Wars That Pitted Doctor vs. Doctor
https://nyti.ms/3a18XTw
https://www.nytimes.com/by/susan-dominus
https://www.audm.com/?utm_source=nytmag&utm_medium=embed&utm_campaign=doctor_vs_doctor_dominus
https://www.nytimes.com/section/magazine
Alex Spyropoulos, a lead researcher at the Feinstein Institutes for Medical Research. Adam Ferguson for The New York Times
Word made it back to a doctor working with Spyropoulos, and that doctor called Hahn to urge her to reconsider, or
at least to get more tests before acting. They exchanged heated words, as the colleague implored her to stay the
course. Hahn pushed back: She had to rely on her clinical judgment and believed that it was unethical to wait for
more information. How could researchers dictate care to a doctor right there at the bedside, especially when a
patients condition was so dire?
The point of contention would be discussed at the May 13 meeting. Dozens of doctors from the Northwell system
videoconferenced in, including Spyropoulos, who was seated in his home in Westchester. Hahns colleagues, a
tightknit unit who had seen one another through so much, sat together in the conference room, occasionally
checking their phones or exchanging glances as the meeting went on. As Spyropoulos recalls, he talked to the group
about the importance of high-quality, randomized trials in making scientific progress, and the risks of trying
experimental treatments without them. I stressed to the group that we should not abandon this principle, even in
the very stressful environment of a pandemic that was overwhelming our hospitals at Northwell, he said. Relying
on gut instinct rather than evidence, he told them, was essentially witchcraft.
For Tsegaye, the word landed like a blow. There was a chill in the air, said Tsegaye, who registered it even by
videoconference. Followed by rapid backpedaling. Spyropoulos quickly explained that he had so much respect for
what those doctors had done he had not been in those critical-care units, in the emergency room, which he knew
were unlike any other he had ever experienced. But it was like a retraction sent to the newspaper the next day,
Tsegaye said. The headline says it all. The retraction the next day? It doesnt have the same impact.
In the days to come, whenever Tsegaye thought about what Spyropoulos said in that meeting, she felt appalled all
over again. She knew that she had never extended herself on behalf of her patients the way she had since March.
She kept flashing back to a day when she was told that a ventilated patients endotracheal tube had fallen out, a
situation that can be fatal for the patient and is also dangerous for the physician: Replacing it requires the doctor to
come into close contact with the patients breath. Tsegaye was putting on her N95 mask to enter the patients room
when its elastic snapped in two. There was no time to go to the supply area to get a new mask. What was the right
thing to do? With a sense of dread, she found her feet and moved toward the patients room. As she prepared to
enter, one of her fellows, whose mask was intact, told her to leave she could manage it on her own.
Looking back, Tsegaye felt that the agony of making those kinds of decisions all day long compounded the grief she
felt while treating so many patients she could not help. These are the decisions we have had to face, Tsegaye said.
For someone like me, who had been in that situation, to have someone tell you that you have been practicing
witchcraft is kind of giving no value to the sacrifice that I have made that my colleagues have made.
Stella Hahn, a pulmonary-critical-care doctor at Long Island Jewish Medical Center. Adam Ferguson for The New York Times
Mangala Narasimhan, a doctor who is in charge of intensive-care units throughout the Northwell Health system. Adam Ferguson for The New
York Times
As doctors face new spikes of Covid-19 cases around the country, they are also confronting a harsh reality: The
viruss deadly secrets remain largely intact. The medical community now has some research-backed drug
treatments remdesivir, an antiviral drug found to shorten hospital stays, and dexamethasone, a cheap, readily
available steroid that seems to cut deaths of patients on ventilators by a third. But six months after the first patient
tested positive on the West Coast, there is still no treatment that reliably slows progression of the illness, much less
a cure. In July, the number of patients dying in this country topped 1,000 five days in a row, according to the Covid
Tracking Project.
In these early months, doctors have faced two unknowns in trying to fight the devastation. The first is the virus
itself: deadly, contagious and entirely novel. The standard of care for most intractable illnesses develops over years,
as doctors build a body of research that tests various theories, compares and contrasts dosages, measures one
drugs power against another. Here doctors were starting from scratch: Any treatment protocol beyond supportive
care oxygen, hydration, antibiotics and ventilation was conjecture. The second, equally novel challenge has
been the sheer scale of the outbreak. Few doctors in this country had encountered the overwhelming volume of
patients, the sense of helplessness, the exhaustion and the desperation to save lives. Hospital administrators found
themselves plunging headlong into making difficult decisions in the absence of strong, unifying federal guidance.
Most did so without the benefit of perfectly parallel case studies or personal experience in hospitals so overrun by
suffering.
When there is no precedent, when there is an information vacuum, decisions are inevitably subject to challenge. In
an already heated environment, some of the worst of the tensions played out between research-oriented doctors and
those who saw themselves primarily as clinicians. Many treating patients on the floor considered it axiomatic that,
with so many dying so fast and so little to go on, they would rely on their experience to make judgment calls about
treatment options. They would try using medications that had been approved for other illnesses but not yet for this
one what the medical community calls off-label uses if they felt they had good reasons to do so. They would
take into consideration any information that was available: the observations of doctors in Milan and China,
conversations among doctors in WhatsApp group texts and in Covid-19 physician Facebook groups, tidbits of
research that made medical sense but had not yet been peer-reviewed.
Remdesivir, an antiviral drug found to shorten hospital stays. Adam Ferguson for The New York Times
Other clinicians, and especially doctors more heavily involved in research, were frustrated that many of their
colleagues were not sufficiently invested in the importance of empirical research to figure out which treatments
worked best and were safest. Kevin Tracey, president of the Feinstein Institutes, tried to emphasize to the doctors
affiliated with the Northwell hospital system that if they were going to try drugs off-label, they should always be
doing so in the context of a clinical research trial: The drug might help some patients but could hurt even more of
them. If that was the case, it was better to know than to operate out of a mix of hope and conviction. He understood,
he said, the impulse for doctors to try drugs off-label out of compassion and the raw emotion of humans trying to
help each other survive and not knowing what to do. But he did not approve of it. Emotions cannot carry the day,
he said. You need evidence-based medicine, and you need clinical trials. You dont make an exception in the middle
of a pandemic.
Ethan Weiss, a cardiologist at the University of California, San Francisco, who specializes in metabolic research,
spent two weeks treating patients at a hospital in New York and was also distressed by how quickly doctors were
trying untested therapies outside clinical trials. I mean, it felt like it wasnt even World War I medicine, he said. It
was almost like Civil War-level medicine. He asked that the name of that New York hospital be withheld out of
respect for his colleagues, whom he knows were not only risking their lives but were also overwhelmed by their
clinical demands and had no research to rely on. He nonetheless was surprised to see many of them making
decisions based on the sort of opinion or written protocol of one or a couple of people that was based on kind of
nothing that I could see, other than just, This seems like a good idea.
Many clinicians on the ground felt the urgency of treating the hundreds of patients dying in front of them;
researchers, with their literal and intellectual distance from the I.C.U., were pressing them to think about the
thousands of patients who were sure to follow to slow down long enough to build a body of evidence that they
knew with more certainty could help. The tensions between these two ways of thinking about medicine have always
existed. But during the early months of the pandemic, the disagreements what one critical-care doctor called, on
his well-read blog, the professions intellectual food fight provided another layer of painful stress to some
doctors already near their limits. It became like Republicans and Democrats, said Pierre Kory, a critical-care
doctor who faced that tension himself at the University of Wisconsin Hospital and Clinics. The two sides cant talk
to each other.
As they prepare to evaluate a given medication or procedure, researchers are expected to approach their task with a
certain neutral mind-set. The official term for that stance sounds both scientific and strangely poetic: clinical
equipoise. Its a point at which a doctors curiosity is greater than her conviction that any one result is the most
likely one. Clinical equipoise is an elegant characterization of a humble admission: I have no idea which of these two
choices is better.
Equipoise gave way to unbridled enthusiasm among some physicians at Lenox Hill Hospital on the Upper East Side
of New York in April when the city was in the thick of the surge. Many doctors there believed they were seeing great
results by providing tocilizumab, an anti-inflammatory drug that tamps down the autoimmune response and is used
for rheumatoid arthritis. The doctors were prescribing the drug, sometimes in conjunction with a steroid, to Covid-
19 patients, particularly those who were not yet on ventilators but whose blood tests suggested that they were about
to take a turn for the worse. In using it, doctors hoped to stave off whats known as a cytokine storm, a potentially
deadly immune-system overreaction in which a torrent of cytokines proteins that can trigger infection-fighting
forces is released. Tocilizumab, which blocks the pathway of a cytokine called IL-6, might prevent that deadly
storm from gathering force. But any anti-inflammatory carries risk, because in fighting inflammation, it can also
hamper the bodys ability to clear the primary infection or others that follow; tocilizumab is also thought to carry
some elevated risk of anaphylactic shock and lower-intestinal perforation.
Dexamethasone is a cheap, readily available steroid that seems to cut deaths of patients on ventilators by a third. Adam Ferguson for The New
York Times
https://www.nytimes.com/2020/04/01/health/coronavirus-cytokine-storm-immune-system.html
Patients with extreme flu in the I.C.U. sometimes received tocilizumab; it is also used to treat cytokine storms that
some cancer patients experience as a side effect of treatment. Doctors at Lenox Hill did not believe it was a leap to
think that the drug could address cytokine storms in Covid-19 patients. They knew that doctors in Milan were
leaning heavily on the drug; they were in conversation with doctors at Yale New Haven Health, considered a
fortress of research-heavy medicine, which also incorporated tocilizumab into their protocol. In addition, some small
studies showed support for the drugs effectiveness, though none were randomized, controlled trials.
I understand that it has never been trialed, John Boockvar, a neurosurgeon at Lenox Hill who is affiliated with the
Feinstein Institutes, told me in late April. (Boockvar is one of the doctors featured on the documentary series
Lenox Hill.) But there is clearly enough data to support its use. The doctors at Lenox Hill had also briefly
participated in a randomized, controlled trial for another drug with a similar mechanism, called sarilumab. But to
Boockvar, enrolling a patient in that trial, which might result in a patient receiving a placebo, posed an ethical
challenge when he could simply prescribe tocilizumab doctors refer to it as toci instead. In April, he learned
that Massachusetts General Hospital was starting a randomized, controlled trial for tocilizumab. If that was my
loved one, he said, imagining a family member who might receive a placebo in that trial, Id be upset. Id think,
Why am I doing this? If its an off-label use with an approved drug give the damn drug to everybody.
At Long Island Jewish, some doctors who were hearing about the drug from colleagues at Lenox Hill, a part of the
Northwell Health consortium, started clamoring for liberal access to it. And yet sometimes, when doctors placed
orders with the hospital pharmacist, their prescriptions were declined; those patients didnt meet criteria Northwell
had established for administering tocilizumab, which was in short supply. Physicians were frustrated that patients
who they believed would benefit from the drug could not receive it. Northwell wanted to be conservative about the
off-label use of drugs outside clinical trials. Theres no proof that anything works! Tsegaye thought at the time.
Everything is experimental! As for enrolling patients in a trial, as overwhelmed as she was, she hardly felt she
was in a position to take that on.
Tsegayes supervisor, Narasimhan, also knew researchers were concerned that in prescribing tocilizumab so readily,
physicians were possibly hampering enrollment in the trial underway at her hospital for sarilumab a patient who
received tocilizumab could not also receive sarilumab. She and her team did not prioritize the trials, she said; they
wanted to provide the drugs they thought were needed. Weve always been allowed to choose treatment, right or
wrong, based on what we thought was best, Narasimhan said in May. And that was gone. It was hard.
In addition to fighting resistance from their administrators, the doctors were sometimes also at odds with their
colleagues, especially infectious-disease doctors, many of whom believed that anti-inflammatories like tocilizumab
and steroids could do more harm than good. Youre killing these patients, one infectious-disease doctor told Hahn
Tocilizumab, which might help prevent a potentially deadly immune-system overreaction but carries the risk of hampering the bodys ability to
clear infections. Adam Ferguson for The New York Times
at Long Island Jewish.
In the Mount Sinai Health System, tocilizumab was also in demand. Administrators felt the stress of making
decisions in the absence of clear data. Judith Aberg, the chief of the division of infectious diseases for Mount Sinai,
fielded demands from doctors working on wards who wanted to use tocilizumab, early and often. I have to give her
credit; she was single-handedly fighting off a lot of pressure from hematologists, said Keren Osman, a Mount Sinai
oncologist and hematologist who was on some of those calls. As experts in blood cancers and diseases,
hematologists had experience working with tocilizumab to treat cytokine storms that were a side effect of some
cancer treatments. She was saying, Im not comfortable just giving patients willy-nilly anything we have we
dont know.
Patients and their families, who heard through the news media about the drug, also started to demand it, even for
Covid-19 patients whose inflammatory markers were normal. People were calling for us to give it, just to give it,
because there were no other therapies, Aberg said. At first, a medical team that included Aberg agreed to put some
patients who were on ventilators on the drug in those patients, it was obvious that systemic inflammation was
Adey Tsegaye, a pulmonary-critical-care doctor at Long Island Jewish Medical Center in Queens. Adam Ferguson for The New York Times
already evident; also, the closer the patient was to dying, the more the risk seemed justified. Eventually, the
thinking at Abergs hospitals and at others evolved to favor use of the drug earlier, before systemic inflammation did
so much damage that the patient was already clinging to life.
By May, doctors at Long Island Jewish and Mount Sinai had stopped pressing for tocilizumab if it was effective, it
was not such a miracle drug that they could see its effects clearly. Many had started to pin their hopes instead on
convalescent plasma, another experimental treatment in which sick patients are given plasma from recovered
patients with antibodies, though its effectiveness is still unknown. We did rush, Aberg says now. I mean, we were
pushed. We were grasping for anything that we could possibly do.
In early July, the drug company studying sarilumab, the drug similar to tocilizumab, announced that it was halting
its trial; researchers found, as Aberg put it, nada. A few weeks later, the pharmaceutical company Roche
announced preliminary results of a tocilizumab trial that was run on Covid patients with pneumonia. The drugs
effects were no better than a placebo. By then, Narasimhan was also starting to see preliminary reports of other
research that showed the drug could, in fact, be dangerous, increasing the risk of fatal secondary and fungal
infections.
My take-home is that I wish we had done more randomized, controlled trials so we could have some real answers,
so that we could tell Florida and Texas, This works, and this doesnt work, Narasimhan, who is now in charge of
intensive-care units throughout the Northwell Health system, told me in July. We could have had so many more
answers in a way that was meaningful. We had this fixation that all these drugs were curative. And they werent.
The story of hydroxychloroquine will most likely be recalled as a classic medical parable of the pandemic. It was a
drug that seemed so promising that physicians were desperate to use it, and researchers were equally driven to see
if it actually delivered the hoped-for results. In the end, the enthusiasm of the first camp most likely slowed the
speed with which the second could study the drug only to find that the enthusiasm was never really justified in
the first place.
In mid-March, Steven Libutti, director of the Rutgers Cancer Institute of New Jersey, read about a small
hydroxychloroquine trial in France that was generating attention, having found that the anti-malarial might be
effective in the treatment of Covid-19. It looked interesting, exciting, promising, but it looked very far from
convincing, Libutti said. Although his specialty is cancer, he wanted to bring his extensive research knowledge to
bear on the pressing question of the drugs effectiveness. He wrote a proposal for a randomized, controlled trial that
would measure the effectiveness of hydroxychloroquine on a patients viral load. (He was comparing the effect of
the drug alone with placebo, as well as with the drug when administered with another drug called azithromycin.)
The Food and Drug Administration and the ethical review board at the Rutgers Cancer Institute approved his trial
in record time, as has been typical for many proposed drug trials during the pandemic. He enrolled the first patient
on April 1, hoping he could easily reach 150, calling on doctors to recruit patients at six hospitals in New Jersey.
By then President Trump had claimed in mid-March that the drug was a game changer. Some doctors in New York
were quietly taking it prophylactically. That month, the F.D.A. authorized hydroxychloroquine for emergency use, a
special dispensation that facilitated doctors access to the drug even outside the context of a trial. Many New York
hospitals standard treatment protocols encouraged doctors to consider hydroxychloroquine for patients, even
though the evidence that it worked remained slim and reports were emerging that in some patients it was causing
heart problems.
Thousands of patients were pouring through those six New Jersey hospitals, but Libutti waited, for weeks, with
great frustration as only a handful of patients were enrolled in his trial each day. Typically, in clinical trials, after a
patient is admitted to the hospital, a doctor or nurse, often affiliated with the research, talks to the patient about the
possibility of enrolling in a clinical trial. But Libuttis team was finding that by the time a nurse could begin the
conversation with the patient, that person had already been administered hydroxychloroquine which meant the
researchers could not get a baseline reading of that patients viral load. Patient after patient was disqualified from
the study. They had been handed hydroxychloroquine along with their toothbrush and slippers when they got to
the emergency room, Libutti told me. They were giving it out like dinner mints. The researcher said he was
shocked by the number of folks whom I thought were incredibly well-read, knowledgeable physicians but were just
panic-prescribing hydroxychloroquine. Ive never seen anything like it. It just shows how lost in the storm folks
were. (Michael Steinberg, who helps oversee trials as well as clinical care at Robert Wood Johnson University
Hospital, which was involved in Libuttis trial, said that although physicians use their clinical judgment to make
decisions about treatment, they strongly encourage doctors to use evidence-based criteria.)
Other doctors shared Libuttis experience. Arthur Caplan, a bioethicist at New York Universitys medical school,
said he is aware of three medical centers where researchers trying to study hydroxychloroquine felt that the early
ardor for the drug among doctors and patients made it difficult for them to recruit subjects to determine,
essentially, whether the embrace of the drug was at all justified. Caplan and a colleague argued, in an article
published online in April in The Journal of Clinical Investigation, that panicked rhetoric about right-to-try must be
aggressively discouraged in order for scientists to learn what regimens or vaccines actually work. Communicating
directly with doctors at various hospitals who were making the drug part of the official protocol, he used more plain
language: This is nuts!
Hydroxychloroquine, the drug that President Trump claimed was a game changer in mid-March. Adam Ferguson for The New York Times
Michelle Ng Gong, the director of critical-care research for the Montefiore Health System in New York. Adam Ferguson for The New York Times
Steven Libutti, the director of the Rutgers Cancer Institute of New Jersey. Adam Ferguson for The New York Times
The Montefiore Health System in New York was one of the many that included hydroxychloroquine as an option in
its treatment protocol, starting in late March. Michelle Ng Gong, the director of critical-care research, did not
actively fight to have the drug removed from the protocol. But when she was working in her capacity as a critical-
care doctor, she does not recall ever prescribing the medication, and she sometimes took patients who had received
it in the emergency room off it. When so many people are dying, you want to do something, she said. But very sick
patients are more susceptible to adverse events. The problem is that we know from critical-care literature, as well
as trials in the past, that we can always do more harm.
The Coronavirus Outbreak
Words to Know About Testing
Confused by the terms about coronavirus testing? Let us help:
Antibody: A protein produced by the immune system that can recognize and
attach precisely to specific kinds of viruses, bacteria, or other invaders.
Antibody test/serology test: A test that detects antibodies specific to the
coronavirus. Antibodies begin to appear in the blood about a week after the
coronavirus has infected the body. Because antibodies take so long to
develop, an antibody test cant reliably diagnose an ongoing infection. But it
can identify people who have been exposed to the coronavirus in the past.
Antigen test: This test detects bits of coronavirus proteins called antigens.
Antigen tests are fast, taking as little as five minutes, but are less
SEE MORE
In the end, the biggest randomized, controlled trial on hydroxychloroquine came out of Britain in June, and
preliminary results found that the drug was not an effective treatment for Covid-19. In contrast to American doctors
whose access to the use of the drug, even outside trials, had been eased by a federal agency, British physicians were
given the opposite message. On April 1, the highest medical officials in England, Wales, Northern Ireland and
Scotland each sent a letter to every hospital in their respective countries, urging doctors not to prescribe
medications off-label outside trials. Instead they encouraged doctors to enroll their patients in large, multicenter,
randomized, controlled trials, like a study run by the University of Oxford called Recovery, which looked at the
efficacy of hydroxychloroquine, tocilizumab, convalescent plasma, dexamethasone and two other treatments. At
some hospitals in Britain, as many as about 60 percent of patients were enrolled in Recovery trials; even the
Northwell system, which is committed to research, was able to enroll, at its most trial-driven hospital, North Shore
University Hospital, around only 20 percent of its patients in clinical trials.
A flood of patients all with the same illness presents logistical challenges to trials, but also the perfect conditions for
them; that the American medical system could not harness more of those patients into randomized, controlled trials,
said Peter Horby, one of the two chief investigators for Oxfords Recovery trials, represents a lost opportunity.
Whether or not convalescent plasma actually h
